Kohlmeier I, Kark JD, Gomez-Gracia E, et al. Stability: Heat sensitive - store at -70 C. Combustible. RESULTS: The lipid profile showed lycopene and astaxanthin decreased total cholesterol, low-density lipoprotein-cholesterol (LDL-C), very LDL-C, and triglycerides and increased high-density lipoprotein-cholesterol level significantly (P < 0.05) compared to the control but less than atorvastatin. Lycopene diet reduces the risk of developing a number of chronic diseases, both the cardiovascular system and internal organs. It is an antioxidant. March 26, 2016. Experimental Density: 350.7 g/mL Biosynth Q-100561: Miscellaneous. 49. Carotenoids may protect low-density lipoprotein from oxidation, a process implicated in the development of atherosclerosis. [3][24] Some foods that do not appear red also contain lycopene, e.g., asparagus, which contains about 30 μg of lycopene per 100-g serving[3] (0.3 μg/g) and dried parsley and basil, which contain around 3.5–7.0 μg/g of lycopene. ↑ Erdman JW Jr, Ford NA, Lindshield BL. Curr Med Chem. [4] The lycopene content of tomatoes depends on variety and increases as the fruit ripens. The dual wavelength procedure should be used and the density of the material checked if the sample is to be added by volume. [4] Ketchup is a common dietary source of lycopene. [27] A 2010 review concluded that research has been insufficient to establish whether lycopene consumption affects human health. In the present work, the effect of lycopene on copper induced oxidation of isolated low‐density lipoprotein (LDL) and the related mechanism were investigated. Two different mean particle sizes (80 and 345 μm) were used at two solvent flow rates (0.792 and 1.35 kg/h). Lycopene and myocardial infarction risk in the EURAMIC study. Lycopene is a key intermediate in the biosynthesis of carotenoids, such as beta-carotene, and xanthophylls. Free Radic Biol Med. The dual wavelength procedure should be used and the density of the material checked if the sample is to be added by volume. [3][4] The median and 99th percentile of dietary lycopene intake have been estimated to be 5.2 and 123 mg/d, respectively. Lycopene is fat-soluble, so the oil is said to help absorption. To remove this staining, the plastics may be soaked in a solution containing a small amount of chlorine bleach. Lipids. Lycopene bioavailability (absorption) can be influenced by many factors. It is found in tomatoes, watermelon and papaya. Gac has high lycopene content derived mainly from its seed coats. In recent epidemiological studies, tissue and serum levels of lycopene, a carotenoid available from tomatoes, have been found to be inversely related to risk of coronary heart disease. Khachik F, Beecher GR, … [4], Plants and photosynthetic bacteria naturally produce all-trans lycopene. There are cases of intolerance or allergic reaction to dietary lycopene, which may cause diarrhea, nausea, stomach pain or cramps, gas, and loss of appetite. [26], Lycopenemia is an orange discoloration of the skin that is observed with high intakes of lycopene. Rousseau EJ, Davison AJ, Dunn B. Increase in low density lipoprotein (LDL) oxidation is hypothesized to be causally associated with increasing risk of atherosclerosis and coronary heart disease. enriched in (very-) low-density lipoprotein fractions [5,6], no physiological function in humans has been described thus far. Lycopene is a compound or a pigment which gives red color to fruits and vegetables such as tomatoes, watermelon, pink grapefruit and guava. Moderate intervention with carotenoid-rich vegetable products reduces lipid peroxidation in men. In early 2009, one study found 10 milligrams of lyocpene per day helps maintain bone density compared to taking only 3 milligrams per day (8) while another study in the same month found 12 milligrams of lycopene per day to be superior to 4 milligrams per day for bone health (9). [23] Cara cara navel, and other citrus fruit, such as pink grapefruit, also contain lycopene. [26] Because lycopene may cause low blood pressure, interactions with drugs that affect blood pressure may occur. The effect of lycopene on macrophage foam cell formation induced by modified low-density lipoprotein (LDL) was studied. Lycopene dissolves in carbon disulfide (1 g/50 mL), boiling ether (1 g/3 L), boiling petroleum ether (1 g/12 L) or hexane at 0 ° C (1 g/14 L). In recent epidemiological studies, tissue and serum levels of lycopene, a carotenoid available from tomatoes, have been found to be invers … [4], Lycopene is not an essential nutrient for humans, but is commonly found in the diet mainly from dishes prepared from tomatoes. Schmidt R, Hayn M, Reinhart B, et al. Lycopene is an open chain unsaturated carotenoid that gives tomatoes, guava, rose hip, watermelon and pink grapefruit its red color. Clin Nephrol 1999;52(1):30-36. Lycopene and its cis isomers were analysed by HPLC with photodiode array detection. Lycopene is not an essential nutrient for humans, but is commonly found in the diet mainly from dishes prepared from tomatoes. Am J Epidemiol. [33] The US Food and Drug Administration (FDA), in rejecting manufacturers' requests in 2005 to allow "qualified labeling" for lycopene and the reduction of various cancer risks, provided a conclusion that remains in effect as of 2017[update]: "...no studies provided information about whether lycopene intake may reduce the risk of any of the specific forms of cancer. [4] Intestinal absorption of lycopene is enhanced by the presence of fat and by cooking. The bleach oxidizes the lycopene, thus allowing the now-polarized metabolite to dissolve. [7], Lycopene is a symmetrical tetraterpene assembled from eight isoprene units. Effect of lycopene on the copper ion-induced low density lipoprotein oxidation in broiler chickens. [3] Although lycopene is chemically a carotene, it has no vitamin A activity. 1998;33(10):981-984.9832077. [14] The discoloration is expected to fade after discontinuing excessive lycopene intake. Full Text PDF [647K] Abstracts References(38) Cited-By(2) Intake of the antioxidant lycopene has been reported to decrease oxidative stress and have beneficial effects on bone health. Increase in low density lipoprotein (LDL) oxidation is hypothesized to be causally associated with increasing risk of atherosclerosis and coronary heart disease. Lycopene is currently the most powerful antioxidant which has been measured in food and is thought to play a role in preventing cancer, heart disease, and macular degeneration. molar density of solvent. Supplementation with tomato juice increases plasma lycopene but does not alter susceptibility to oxidation of low-density lipoproteins from renal transplant recipients. Lipids. March 26, 2016. Kyung-Woo Lee, Won-Don Choo, Chang-Won Kang and Byoung-Ki AnEmail author Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. [4] When exposed to light or heat, lycopene can undergo isomerization to any of a number of cis-isomers, which have a bent rather than linear shape. Heat sensitive - store at -70 C. Combustible. There are various benefits of lycopene; it helps in reducing risk of certain types of cancers, heart disease and macular degeneration. [14], A 2017 review concluded that tomato products and lycopene supplementation had small positive effects on cardiovascular risk factors, such as elevated blood lipids and blood pressure. OU Chemical Safety Data (No longer updated) More details: Safety: GHS07 Biosynth Q-100561: H315; H319; H335 Biosynth Q-100561: Minimize contact. Lycopene extraction from tomatoes, as a promising health-promoting functional food ingredient, is drawing increasing attention by the food industry. Lycopene is almost insoluble in methanol or ethanol, but is soluble in chloroform or benzene. ω . Several human epidemiological studies, supplemented by in vivo and in vitro studies, have shown decreased bone loss following the consumption of lycopene/tomato. [4] Although gac (Momordica cochinchinensis Spreng) has the highest content of lycopene of any known fruit or vegetable (multiple times more than tomatoes),[17][18] tomatoes and tomato-based sauces, juices, and ketchup account for more than 85% of the dietary intake of lycopene for most people. Each extension in this conjugated system reduces the energy required for electrons to transition to higher energy states, allowing the molecule to absorb visible light of progressively longer wavelengths. In animal models of atherosclerosis, lycopene and tomato products decreased plasma total cholesterol, LDL cholesterol and increased high-density lipoprotein cholesterol. There are various benefits of lycopene; it helps in reducing risk of certain types of cancers, heart disease and macular degeneration. ; Tomato lycopene and low-density lipoprotein oxidation: a human dietary intervention study. However, unlike other carotenoids, lycopene levels in serum or tissues do not correlate well with overall intake of fruits and vegetables. Because of its non-polarity, lycopene in food preparations will stain any sufficiently porous material, including most plastics. [4] Synthesis begins with mevalonic acid, which is converted into dimethylallyl pyrophosphate. Studies show that lycopene intake is significantly associated with lower risk of lung, colon and stomach carcinogenesis. Lycopene (from the neo-Latin Lycopersicum, the tomato species) is a bright red carotenoid hydrocarbon found in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, grapefruits, and papayas, but it is not present in strawberries or cherries. However, a diet high in olive oil and rich in lycopene may decrease the risk of coronary heart disease by improving the serum lipid profile compared with a high-carbohydrate, low-fat, lycopene-rich di … In the present work, the effect of lycopene on copper induced oxidation of isolated low‐density lipoprotein (LDL) and the related mechanism were investigated. [4] It is insoluble in water. Although this is promising, more high-quality research is needed in this area. Lycopene, CAS: 502-65-8, is a highly conjugated antioxidant carotenoid compound. LDL was isolated from plasma by ultracentrifugation. CopyCopied, InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+ However, in vitro enrichment with either lutein or lycopene actually enhanced oxidation of the LDL. Lycopene more sensitive to the oxidation reaction, the solution after 12 hours by sunlight, which basically wiped out of lycopene. These Secondary Standards are qualified as Certified Reference Materials. Two molecules of this product are then condensed in a tail-to-tail configuration to give the 40-carbon phytoene, the first committed step in carotenoid biosynthesis. [4][22], Cooking and crushing tomatoes (as in the canning process) and serving in oil-rich dishes (such as spaghetti sauce or pizza) greatly increases assimilation from the digestive tract into the bloodstream. Research suggests that increased lycopene intake may reduce the risk of lung cancer. Tomato lycopene and low density lipoprotein oxidation: a human di- etary intervention study. Density functional theory has been applied to optimize the configurations of the ground and excited states of lycopene and oxygen respectively. Insoluble dans l’eau, le lycopène est transporté par les lipides du sang et s’accumule dans certains organes, en particulier dans le foie et la prostate. High lycopene foods include guavas, cooked tomatoes, watermelon, grapefruit, papaya, sweet red peppers, persimmon, asparagus, red cabbage, and mangos. Serum lycopene level changes with dietary lycopene intake irrespective of the amount of fat intake. BENEFITS OF LYCOPENE. If not diluted the amount of lycopene in the assay may be too high, leading to either incomplete extraction or too high of an absorbance value. [4] Like all carotenoids, lycopene is a tetraterpene. Laboratory of Poultry Nutrition, Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University. Lycopene and tomatoes as treatment for osteoporosis So, since we’re on the subject of Osteoporosis today, I’m going to share a few ways for you to reap the benefits of tomatoes in your meals and snacks so that you can soak up the lycopene for your body to enjoy all year long- even if you don’t have tomato plants growing in your garden. Lycopene is especially interesting because of its considerable antioxidant activity that highly exceeds that of b-carotene and a-tocopherol [7,8]. It is a member of the carotenoid family of compounds, and because it consists entirely of carbon and hydrogen, is also a carotene. The quenching mechanism of singlet oxygen by lycopene is analyzed based on the calculations at the B3LYP/6-311+(d,p) level. Because of its lipophilic nature, lycopene concentrates in low-density and very-low-density lipoprotein fractions of the serum. (2011): 1146-1163.” tomato extract effect on hypertension. 48. [4], In plants, algae, and other photosynthetic organisms, lycopene is an intermediate in the biosynthesis of many carotenoids, including beta-carotene, which is responsible for yellow, orange, or red pigmentation, photosynthesis, and photoprotection. Lycopene may affect the immune system, the nervous system, sensitivity to sunlight, or drugs used for stomach ailments. [13] Abstract The molecular structural and Raman spectroscopic characteristics of β‐carotene and lycopene are investigated by density functional calculations. Serum lycopene level changes with dietary lycopene intake irrespective of the amount of fat intake. Because of its lipophilic nature, lycopene concentrates in low-density and very-low-density lipoprotein fractions of the serum. )", Journal of Agricultural and Food Chemistry, "Influence of cooking procedure on the bioavailability of lycopene in tomatoes", "Carotenoid pigments in GAC fruit (Momordica cochinchinensis SPRENG)", "Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis", "An Update on the Health Effects of Tomato Lycopene", "Lycopene and tomato and risk of cardiovascular diseases: A systematic review and meta-analysis of epidemiological evidence", "Qualified Health Claims: Letter Regarding Tomatoes and Prostate Cancer (Lycopene Health Claim Coalition) (Docket No. ↑ Bub A, Watzl B, Abrahamse L, et al. Abstract The molecular structural and Raman spectroscopic characteristics of β‐carotene and lycopene are investigated by density functional calculations. 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A-Tocopherol [ 7,8 ] of visible light, so it appears red dual wavelength procedure should be used and structure! Studies, have shown decreased bone loss following the consumption of lycopene/tomato Heat sensitive - store at -70 C...