There is no data available. Product identifier Product name Fumaric acid Product number FF23617 CAS number 110-17-8 EC number 203-743-0 1.2. Incompatible Materials Bases, Strong oxidizing agents, Reducing Agent Hazardous Decomposition ProductsCarbon monoxide (CO), Carbon dioxide (CO2) Hazardous Polymerization Hazardous polymerization does not occur. Its E number is E297. Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, of substances in closed systems with minimal release and in the production of articles. When heated to decomposition it emits irritating fumes and acrid smoke [Lewis, 3rd ed., 1993, p. 790]. According to the annexes to the directive, storage areas and containers containing chemical substances or mixtures that are classified as hazardous according to the CLP Regulation (1272/2008/EC) must be marked and/or labeled. Exposure to moist air or water. SAFETY DATA SHEET Fumaric Acid Issued: 01/06/2015 Page 2 Signal Word: Warning Hazard Statements: H319 Causes serious eye irritation. Substances for which classification and labelling data have been notified to ECHA by manufacturers or importers. Other release to the environment of this substance is likely to occur from: indoor use (e.g. Contact with skin: May cause skin irritation. Agricultural chemicals from maleic anhydride include pesticides, herbicides and growth regulators. This website uses cookies to ensure you get the best experience on our websites. The trans isomer possesses a dipole moment. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. This substance can be found in products with material based on: plastic (e.g. * Breathing Fumaric Acid can irritate the nose and throat causing coughing and wheezing. : 682001: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. 7. This substance is used for the manufacture of: machinery and vehicles, furniture and electrical, electronic and optical equipment. This substance is used in the following products: adhesives and sealants, coating products, inks and toners, laboratory chemicals and cosmetics and personal care products. FUMARIC ACID: ICSC: 1173 (E)-2-Butenedioic acid trans-1,2-Ethylenedicarboxylic acid Allomaleic acid Boletic acid: June 2011: CAS #: 110-17-8 EC Number: 203-743-0 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. Welcome to PubChem! 0000003285 00000 n SLIGHTDust explosion possible if in powder or granular form, mixed with air.FUMARIC ACID is a carboxylic acid. Pennsylvania RTK: Fumaric acid Massachusetts RTK: Fumaric acid TSCA 8(b) inventory: Fumaric acid CERCLA: Hazardous substances. Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. Fumaric acid is sometimes found in processed foods such as smoked meats. : 110-17-8 EINICS EC-No. Hazardous overview: Fumaric Acid E297 is Slightly hazardous in case of inhalation, skin contact, ingestion or eye contact. ... fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid . If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically generated for the InfoCard. When heated in sealed vessels with water at 150 - 170\u00b0C it forms DL-malic acid. Other release to the environment of this substance is likely to occur from: outdoor use and indoor use as processing aid. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). SAFETY DATA SHEET: FUMARIC ACID FUMARIC ACID F765.32 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 HO2CCH:CHCO2H 116.07 7.1. 0000002258 00000 n Other Classifications: WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC). Fumaric Acid | Structure, Uses, Hazards, & Properties | - Genuine chemistry - The ultimate resource for Chemistry. The quality and correctness of the information submitted to ECHA remains the responsibility of the data submitter. There is no data available. 0000005379 00000 n A substance identified primarily by an EC or list number may be linked with more than one CAS number, or with CAS numbers that have been deleted. What is the Classification and Labelling Inventory? Fumaric acid Revision Date 26-Jan-2018 Sensitivity to Mechanical ImpactNo information available Sensitivity to Static DischargeNo information available Specific Hazards Arising from the Chemical Fine dust dispersed in air may ignite. in case of consumer and professional uses). Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. RTECS # LS9625000 ... Synonyms. 7.4. The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. Hazardous Reactions None under normal processing. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). Y]����Uǃ[�nШ뾛%4Ne���]ֵ���?5��!��! What Is Fumaric Acid E297? Fumaric Acid GHS SDS, MSDS Sheet, Material Safety Data Sheet. This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). Prolonged contact with eyes or skin may cause irritation. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant), of ingestion. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Pre-Registration process, Other, CAD - Chemical Agents Directive, Art. 75 hospitalized patients (42 female, 33 males, age 20 to 91) were dosed with 500 mg fumaric acid/day for one year. Supplemental Hazard none Page 1 of 7 Fumaric Acid CAS No 110-17-8 MATERIAL SAFETY DATA SHEET SDS/MSDS . OTHER HAZARDS FIRE AND EXPLOSION HAZARD: May form combustible dust concentrations in air. 0000003207 00000 n In that case, the ATP (Adaptation to Technical Progress) number is displayed. It is recommended that all dust Fumarsäure . Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Hazard Symbols: XN Risk Phrases: R 22 Harmful if swallowed. While the harmonized list covers many hazardous substances, other ones not listed may also meet the classification criteria in accordance with the CLP. Product Identification. Fumaric acid-1,4-13 C 2,2,3-d 2 2 Product Results | Match Criteria: Product Name More information about CAS and the CAS registry can be found here. It is approved for use as a food additive in the EU, USA and Australia and New Zealand. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. Product name : Fumaric acid Catalog No. Fumaric acid CAS-No. 0000001775 00000 n The ‘Hazard classification’ and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. They react in this way with all bases, both organic (for example, the amines) and inorganic. food packaging and storage, toys, mobile phones). Fumaric acid or trans-butenedioic acid has the formula HOOC-CH=CH-COOH (C 4 H 4 O 4). the products in which the substance may be used) may refer to uses as intermediate and under controlled conditions, for which there is no consumer exposure. Persistence and degradability FUMARIC ACID CRS(110-17-8) Biodegradation 98 12.3. Product Name: Fumaric acid Product Code: 106301 Chemical Name: Fumaric acid Index No: 607-146-00-X CAS No: 110-17-8 Chronic: Not expected to be a chronic hazard. As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. Skin: Causes mild skin irritation. It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. 0000032684 00000 n +49 34291 3372-36 Fax. 29 0 obj<> endobj At sufficiently high doses the material may be nephrotoxic(i. e. Please upgrade your Internet Explorer to a newer version. 2 Emergency First Aid: Get Medical Assistance For All Cases Of Overexposure. Substances for which an agreed set of classification and labelling data has been agreed at EU level by Member States. Substances listed in the EINECS, ELINCS, or NLP inventories. ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes. Carboxylic acids donate hydrogen ions if a base is present to accept them. If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. In fumaric acid the carboxylic acid groups are trans and in maleic acid they are cis. Use of water jet may cause explosive dust conditions. Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, EU. 0000001405 00000 n 66/2010/EC, L 27/1, 30 Jan 2010 (T. 3 of Anx VI to CLP; Candidate List of SVHCs), EU. Fumaric Acid Flinn Scientific, Inc. P.O. 0000046174 00000 n Eliminate Any Ignition Until The Area Is Determinded To Be Free From Explosion Or Fire Hazards. FUMARIC ACID CRS(110-17-8) LC50 fishes 1 245 mg/l LC50-96 Hour - fish (48h) EC50 Daphnia 1 204 - 220 mg/l EC50 - 48 Hour - Daphnia magna 12.2. This substance is used in the following products: polymers, adhesives and sealants, coating products, inks and toners and pharmaceuticals. Structure, properties, spectra, suppliers and links for: Fumaric acid, 110-17-8. endstream endobj 30 0 obj<. Precautionary Statements Prevention: Wash thoroughly after handling. FUMARIC ACID: ICSC: 1173 (E)-2-Butenedioic acid trans-1,2-Ethylenedicarboxylic acid Allomaleic acid Boletic acid: June 2011: CAS #: 110-17-8 EC Number: 203-743-0 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. It is soluble in alcohol, slightly soluble […] It is generally used in beverages and baking powders for which requirements are placed on purity. Other: Consult professionals if Fumaric Acid need to be handled under some special conditions. Fumaric Acid E297 is often used as an acidulant and acidity regulator in beverages, pudding mixes, etc. Substances may have impurities and additives that lead to different classifications. : 682001: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. This database contains: (1) the list of hazardous substances harmonized for classification and labeling in EU (i.e. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. P264 Wash hands thoroughly after handling. Chemsrc provides fumaric acid(CAS#:110-17-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Contact with eyes: May cause eye irritation. Fumaric Acid SDS details show. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. Pennsylvania RTK: Fumaric acid Massachusetts RTK: Fumaric acid TSCA 8(b) inventory: Fumaric acid CERCLA: Hazardous substances. 7.1. The molecular structure is based on structures generated from information available in ECHA’s databases. This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. This section provides links to the list of precautions (precautionary statements) and to the guidance on safe use, if they have been provided in REACH registration dossiers. SAFETY DATA SHEET Fumaric Acid Issued: 01/06/2015 Page 2 Signal Word: Warning Hazard Statements: H319 Causes serious eye irritation. Substances Rendering Goods Ineligible for EU Ecolabel, Art. Note that this list is not exhaustive. Other Classifications: WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC). Fumaric Acid Trans-butenedioic Acid, trans-1,2-Ethylenedicarboxylic acid 2-Butenedioic acid Allomaleic acid Boletic acid Donitic acid Lichenic acid Solid, White Crystalline. 607-146-00-X For the full text of the H-Statements mentioned in this Section, see Section 16. 110-16-7 Revision Date 2007-03-01 Pennsylvania Right To Know Components Maleic acid CAS-No. This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing. 1.1 Product identifier. Substances which have been registered and can be placed on the EEA market by those companies with a valid registration. Statements 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and 2(b)(i), Directive 98/24/EC on Protection of Workers from Chemical Agent-related Risks, 5 May 1998 (Table 3 of Annex VI to CLP, as amended), EU. SARA 311/312 Hazards Acute Health Hazard Massachusetts Right To Know Components Maleic acid CAS-No. Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening. This substance is used in the following areas: formulation of mixtures and/or re-packaging and scientific research and development. Philip Lutze, in Distillation, 2014. fumaric acid 110-17-8 > 99 Section 4 - FIRST AID MEASURES SWALLOWED If swallowed do NOT induce vomiting. This white crystalline compound is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid. 0000001325 00000 n Warning! Moderately toxic. This site is not fully supported in Internet Explorer 7 (and earlier versions). 7.3. : Fumaric acid Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. Gives off irritating or toxic fumes (or gases) in a fire. Skin : Wash Thoroughly With Soap And Water. S 28A After contact with skin, wash immediately with plenty of water There's a medical application for … 106301-Fumaric acid Version: 2 Revision date: 19/04/2016 Page 1 of 8 Print date: 19/04/2016 -Continued on next page.-SECTION 1: IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY/UNDERTAKING. Fumaric acid According to Regulation (EC) No 1907/2006, Annex II, as amended. : Fumaric acid Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). The EC or list number is the primary substance identifier used by ECHA. A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. Welcome to PubChem! Fumaric acid uses include paper sizing, food acidulant and UPR manufacture. Isolate from incompatible substances. Special Hazards of Combustion Products: Irritating smoke containing maleic anhydride may form in fire. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. HAZARDS IDENTIFICATION Hazards Not Otherwise Classified: No information available Signal Word: WARNING OSHA Classification: Hazard Category: Hazard Statement: Eye Damage/Irritation 2A Causes serious eye irritation. inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. MALEIC ACID is a colorless to white crystalline solid. The described Product category (i.e. Hazardous overview: Fumaric Acid is Slightly hazardous in case of inhalation, skin contact, ingestion or eye contact. GHS product identifier Other means of identification Product type Section 1. SECTION 6 : Accidental release measures Personal precautions, protective equipment and emergency procedures: Wear protective equipment. Their reactions with bases, called "neutralizations", are accompanied by … 0000004719 00000 n Fumaric acid-2,3-d2 | C4H4O4 | CID 12201062 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. This is unique source of information on the chemicals manufactured and imported in Europe. This substance is used in the following products: laboratory chemicals, adhesives and sealants, plant protection products, inks and toners and pH regulators and water treatment products. Slightly hazardous in case of skin contact (irritant, permeator), of The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. Fumaric acid: Catalog No. EU. 0000008487 00000 n R 36/37/38 Irritating to eyes, respiratory system and skin. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. Fumaric acid None identified 2. Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, not of the presence of the substance in other articles or mixtures. 5.2 SPECIFIC HAZARDS FIRE AND EXPLOSION HAZARD: Possibility of dust explosion. The date of the last update corresponds to the publication date of the InfoCard and not necessarily to the date in which the update occurred in the source data. : 203-743-0 Molecular Weight: 116.07 Chemical Formula: HOOCCH=CHCOOH . Commission Regulation (EU) No 2015/830 of 28 May 2015. Precautionary Statements: P280 Wear protective gloves/protective clothing/eye protection/face protection. Ingestion: No hazard expected in normal industrial use. 110-17-8 Eye Irrit. We apologise for the inconvenience in the meantime. Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and as processing aid. Its chemical formula is HO 2 CCH=CHCO 2 H. Maleic acid is the cis-isomer of butenedioic acid, whereas fumaric acid is the trans-isomer.It is mainly used as a precursor to fumaric acid, and relative to its parent maleic anhydride, maleic acid has few applications. Contact with eyes: May cause eye irritation. Fumaric acid … 8.5.1.1 Succinic, fumaric, and malic acid. 32 0 obj<>stream 0000001584 00000 n 0000001188 00000 n DERMAL (LD50): Acute: 20000 mg/kg [Rabbit]. Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. FUMARIC ACID 110-17-8 99.5. Identification::: Fumaric Acid SAFETY DATA SHEET Product code:Not available. FUMARIC ACID FINE 5.1 EXTINGUISHING MEDIA Water spray, dry powder, carbon dioxide or media appropriate for surrounding fire. HAZARD SUMMARY * Fumaric Acid can affect you when breathed in. 6.5. While fumaric acid itself may be safe, remember that there's risk associated with eating some of the foods in which it appears. - Find MSDS or SDS, a COA, data sheets and more information. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. This substance is used for the manufacture of: chemicals. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Prevent dust build-up by providing adequate ventilation. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. This substance has an industrial use resulting in manufacture of another substance (use of intermediates). Containers of Fumaric Acid may be hazardous when empty since they retain product residues (dust, solids); observe all … According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation. 7.1. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. 0000007270 00000 n %PDF-1.5 %���� Inhalation: Inhalation of dust may cause respiratory tract irritation. Ingestion: No hazard expected in normal industrial use. Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. 0000003770 00000 n Fumaric acid is prepared: (1) By boiling maleic acid with hydrochloric acid or sodium hydroxide. REACH registration dossiers have greater data requirements (such as supporting studies) than do notifications under CLP. Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Guidance on the safe use of the substance, PACT - Public activities Co-ordination Tool, CAD - Chemical Agents Directive,Art. The type of uses and classifications may vary between different submissions to ECHA and for a full understanding it is recommended to consult the source data. The EC Number is the numerical identifier for substances in the EC Inventory. 110-16-7 Revision Date 2007-03-01 New Jersey Right To Know Components Maleic acid CAS-No. Related Pages. If the substance is covered by more than one CLH entry (e.g. FUMARIC ACID: ICSC: 1173 (E)-2-Butenedioic acid trans-1,2-Ethylenedicarboxylic acid Allomaleic acid Boletic acid: June 2011: CAS #: 110-17-8 EC Number: 203-743-0 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. * Contact can irritate and burn the skin and eyes. This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). The ‘Hazard classification and labelling’ section shows the hazards of a substance through a standardised system of statements and pictograms, as has been established under CLP ... fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid. Show this safety data sheet to the doctor in attendance. Table 3 of Annex VI to CLP Regulation); and (2) the Candidate List of substances of very high concern (SVHC). 0000009127 00000 n 110-17-8 Fumaric acid 99% 203-743-0 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes. REACH registered substance data was upgraded on 9th November. 0000000016 00000 n The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). 75 hospitalized patients (42 female, 33 males, age 20 to 91) were dosed with 500 mg fumaric acid/day for one year. Also referred to as the Plastics Implementation Measure (PIM), this Regulation provides the Union List of monomers and other substances authorized in the manufacture of food contact plastics. Product Name: FUMARIC ACID Revision Date: 03.06.2019 Page 3 of 6 5. Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 0000003241 00000 n HAZARDS IDENTIFICATION 2.1 GHS classification PHYSICAL HAZARDS Not classified HEALTH HAZARDS Not classified ENVIRONMENTAL HAZARDS Not classified 2.2 GHS label elements, including precautionary statements Pictograms or hazard symbols None